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Postdoctoral Researcher - Breast Cancer

Toronto, ON
  • Number of positions available : 1

  • To be discussed
  • Full time
  • Starting date : 1 position to fill as soon as possible

The University Health Network, where “above all else the needs of patients come first”, encompasses Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute and the Michener Institute of Education. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of ground breaking firsts and a purpose of “Transforming lives and communities through excellence in care, discovery and learning”, the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.

Position Summary

The Nguyen lab is looking for a motivated postdoctoral researcher to work on an exciting project in breast cancer. The lab is led by Dr. Long Nguyen, a clinician scientist and breast medical oncologist, and affiliated with both the Department of Medicine, and the Department of Medical Biophysics at the University of Toronto. The lab is located at the Princess Margaret Cancer Centre in the Research Tower within the MaRS building.

https://lvnguyenlab.ca/

Our research program is focused on breast cancer. We are interested in understanding the mechanisms that regulate cancer stem cell activity in human breast cancer, how these contribute to disease progression, relapse and treatment resistance, with the goal of designing new effective treatment strategies. We work with human cancer cell lines, patient-derived xenograft models and patient-derived organoid models. We apply advanced clonal tracking strategies in conjunction with single cell sequencing platforms to study the link between phenotype, genotype and function at clonal and single cell resolution.

The successful applicant will be designing and leading their own research project to identify cell states and molecular mechanisms that control cancer stem cells in human breast cancer models. This work is anticipated to involve single cell sequencing, flow cytometry, cell culture and CRISPR/Cas9 gene editing on both patient-derived xenograft models and patient-derived organoid models. Collaboration with industry and international academic partners is a possibility depending on the success of the project.

Duties

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.


Requirements

Level of education

undetermined

Work experience (years)

undetermined

Written languages

undetermined

Spoken languages

undetermined