Postdoctoral Researcher - Breast Cancer

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Position Summary

The Nguyen lab is looking for a motivated postdoctoral researcher to work on an exciting project in breast cancer. The lab is led by Dr. Long Nguyen, a clinician scientist and breast medical oncologist, and affiliated with both the Department of Medicine, and the Department of Medical Biophysics at the University of Toronto. The lab is located at the Princess Margaret Cancer Centre in the Research Tower within the MaRS building.

https://lvnguyenlab.ca/

Our research program is focused on breast cancer. We are interested in understanding the mechanisms that regulate cancer stem cell activity in human breast cancer, how these contribute to disease progression, relapse and treatment resistance, with the goal of designing new effective treatment strategies. We work with human cancer cell lines, patient-derived xenograft models and patient-derived organoid models. We apply advanced clonal tracking strategies in conjunction with single cell sequencing platforms to study the link between phenotype, genotype and function at clonal and single cell resolution.

The successful applicant will be designing and leading their own research project to identify cell states and molecular mechanisms that control cancer stem cells in human breast cancer models. This work is anticipated to involve single cell sequencing, flow cytometry, cell culture and CRISPR/Cas9 gene editing on both patient-derived xenograft models and patient-derived organoid models. Collaboration with industry and international academic partners is a possibility depending on the success of the project.

Duties

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

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We thank all applicants for their interest, however, only those selected for further consideration will be contacted.